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1.
Nutr. hosp ; 28(2): 545-552, mar.-abr. 2013. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-115784

RESUMO

Introduction: Evidences suggest that fat intake, visceral obesity and intracellular lipids are related to insulin impairment. Objective: The objective of the present paper was correlate visceral obesity and metabolic alterations in control (CTR) and hyperlipidic cafeteria diet (CFT) fed animals. Methods: After 6 months of diet treatment, liver and muscle of the male rats were utilized to determined glucose uptake and glycogen metabolism after administration of 0.4I U/kg insulin in vivo, and correlate the visceral adiposity to these two parameters. Results: Ample range of physiologic answers to body composition in metabolic profile of the both diets was found. No differences were found in glycemia and triacylglycerol after insulin action in both groups, however CFT group accumulated higher adiposity, mostly visceral fat, and showed lower glycogen content in the liver. We also found an inverse correlation between visceral adiposity and glucose uptake and a decrease of the glycogen synthase active form in the liver. CTR animals demonstrated an inverse correlation between glucose uptake and visceral adiposity in the muscle. Discussion and conclusion: It was observed a variability of metabolic alterations in animals which can be related to degree of accumulation of abdominal adiposity and ingestion of diet fats. Further studies will be required to clarify the reasons for the observed liver alterations in CFT and muscle alterations in CTR animals (AU)


Introducción: Las evidencias sugieren que la ingesta de grasas, obesidad visceral y lípidos intracelulares están relacionados con resistencia a la acción de la insulina. Objetivo: El objetivo del presente trabajo fue correlacionar la obesidad visceral con alteraciones metabólicas en los animales controles (CTR) y alimentados con la dieta de cafeteria hiperlipidica (CFT). Metodos: Después de 6 meses de tratamiento con dieta, el hígado y lo musculo esqueletico de los ratones se utilizaron para determinar la captación de glucosa y el metabolismo del glucógeno después de la administración de la insulina 0.4 UI/kg in vivo y correlacionar la adiposidad visceral a estos dos parámetros. Resultados: Una amplia gama de respuestas fisiológicas a la composición corporal era encontrado. No se encontraron diferencias en la glucemia y triglicéridos después de la acción de la insulina en ambos grupos, sin embargo CFT grupo acumuló mayor adiposidad, principalmente adiposidad visceral, y mostraron menor contenido de glucógeno en el hígado. También se encontró una correlación inversa entre la adiposidad visceral y la captación de glucosa y una disminución de la forma activa de la enzima glucógeno sintasa en el hígado. Animales CTR demostrado una correlación inversa entre la captación de glucosa y la adiposidad visceral en el músculo. Discusión y conclusiones: Se observó una gran variabilidad de alteraciones metabólicas en los animales que se pueden relacionados con las tasas de acumulación de la adiposidad visceral y la ingestión de grasas dietéticas. Más estudios serán necesarios para aclarar las razones de las alteraciones observadas en el hígado de los animales CFT y las alteraciones musculares en animales CTR (AU)


Assuntos
Animais , Dieta Hiperlipídica , Metabolismo dos Lipídeos/fisiologia , Glucose/metabolismo , Glicogênio/metabolismo , Resistência à Insulina , Hiperlipidemias , Tecido Adiposo , Gordura Abdominal
2.
Clinics (Sao Paulo) ; 67(10): 1209-14, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23070349

RESUMO

OBJECTIVES: The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life. METHOD: The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial and venous catheters were implanted for arterial pressure measurements, drug administration, and blood sampling. Baroreflex sensitivity was evaluated according to the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine infusion, respectively. Sympathetic and vagal effects were determined by administering methylatropine and propranolol. RESULTS: Body weight, Lee index, and epididymal white adipose tissue values were higher in the monosodium glutamate group in comparison to the control group. The monosodium glutamate-treated rats displayed insulin resistance, as shown by a reduced glucose/insulin index (-62.5%), an increased area under the curve of total insulin secretion during glucose overload (39.3%), and basal hyperinsulinemia. The mean arterial pressure values were higher in the monosodium glutamate rats, whereas heart rate variability (>7 times), bradycardic responses (>4 times), and vagal (~38%) and sympathetic effects (~36%) were reduced as compared to the control group. CONCLUSION: Our results suggest that obesity induced by neonatal monosodium glutamate treatment impairs cardiac autonomic function and most likely contributes to increased arterial pressure and insulin resistance.


Assuntos
Sistema Nervoso Autônomo/efeitos dos fármacos , Fenômenos Fisiológicos Cardiovasculares/efeitos dos fármacos , Aditivos Alimentares/efeitos adversos , Coração/efeitos dos fármacos , Obesidade/induzido quimicamente , Glutamato de Sódio/efeitos adversos , Animais , Animais Recém-Nascidos , Pressão Arterial/efeitos dos fármacos , Sistema Nervoso Autônomo/fisiopatologia , Modelos Animais de Doenças , Coração/fisiopatologia , Frequência Cardíaca/efeitos dos fármacos , Hemodinâmica/efeitos dos fármacos , Insulina/sangue , Resistência à Insulina , Masculino , Obesidade/fisiopatologia , Ratos , Ratos Wistar , Fatores de Tempo
3.
Clinics ; 67(10): 1209-1214, Oct. 2012. ilus, tab
Artigo em Inglês | LILACS | ID: lil-653486

RESUMO

OBJECTIVES: The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life. METHOD: The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial and venous catheters were implanted for arterial pressure measurements, drug administration, and blood sampling. Baroreflex sensitivity was evaluated according to the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine infusion, respectively. Sympathetic and vagal effects were determined by administering methylatropine and propranolol. RESULTS: Body weight, Lee index, and epididymal white adipose tissue values were higher in the monosodium glutamate group in comparison to the control group. The monosodium glutamate-treated rats displayed insulin resistance, as shown by a reduced glucose/insulin index (-62.5%), an increased area under the curve of total insulin secretion during glucose overload (39.3%), and basal hyperinsulinemia. The mean arterial pressure values were higher in the monosodium glutamate rats, whereas heart rate variability (>7 times), bradycardic responses (>4 times), and vagal (~38%) and sympathetic effects (~36%) were reduced as compared to the control group. CONCLUSION: Our results suggest that obesity induced by neonatal monosodium glutamate treatment impairs cardiac autonomic function and most likely contributes to increased arterial pressure and insulin resistance.


Assuntos
Animais , Masculino , Ratos , Sistema Nervoso Autônomo/efeitos dos fármacos , Fenômenos Fisiológicos Cardiovasculares/efeitos dos fármacos , Aditivos Alimentares/efeitos adversos , Coração/efeitos dos fármacos , Obesidade/induzido quimicamente , Glutamato de Sódio/efeitos adversos , Animais Recém-Nascidos , Pressão Arterial/efeitos dos fármacos , Sistema Nervoso Autônomo/fisiopatologia , Modelos Animais de Doenças , Frequência Cardíaca/efeitos dos fármacos , Coração/fisiopatologia , Hemodinâmica/efeitos dos fármacos , Resistência à Insulina , Insulina/sangue , Obesidade/fisiopatologia , Ratos Wistar , Fatores de Tempo
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